Venous Wound Evidence Based Treatment Pathway

This Venous Wound Evidence Based Treatment Pathway is based from documents such as the RNAO and WOCN guidelines. I have revised them in a time related format that is based on predictive modeling evidence.

Week 1: Venous Wound Evidence Based Treatment Pathway

  1. Confirm Venous Etiology              Venous Duplex Ultrasound
  2. Rule Out Arterial Etiology             ABI
  3. Apply Compression                         Multilayer compression
  4. Remove avascular tissue                Debride Non-Viable Tissue
  5. Optimize Nutrition                          Dietary Consultation
  6. Protect Surrounding Tissue           Barrier Paste
  7. Control Moisture                             Absorbent Dressing

Week 4 Venous Wound Evidence Based Treatment Pathway: If the venous leg ulcer heals less than 30% over the first 4 weeks* then consider the following adjunctive therapies or treatments:

  1. Sponsor Granulation                       NPWT
  2. Introduce  Growth Factors            Skin Substitute
  3. Revisit diagnosis                              Rule Out Associated Etiologies

24 Week Benchmark:  A benchmark 49% of the venous ulcers treated with compression therapy alone in the control arm of a randomized clinical trial healed at 24 weeks¹.

*Note: “Data suggests that a venous leg ulcer that fails to decrease in size by 30% (percentage area reduction) of its initial size over the first 4 weeks of treatment has a 68% probability of failing to heal within 24 weeks”².

1. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with allogeneic cultured human skin equivalent. Arcj Dermatol 1998;134:293-300.

2. Kanter J, Margolis D, A multicenterstudy of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br. J Dermatol. 2000;142(5):960-964.)

Venous Wounds and VAC Therapy

Matthew…great blog and great wound info!! Tell me – what has been your experience with using VAC on a venous stasis ulcer? Any tricks for helping to keep the seal with the weeping? Also do you apply light compression over the VAC? I have never had a good experience with this and spend most of my time patching the seal,, but thought you might have some creative tips. I appreciate it…thanks so much!

A

Dear A, Great Question.  The first decision I make when choosing negative pressure (VAC) for venous etiology wounds is which types of venous wounds I would exclude. Limiting conditions or symptoms include:

1. Infection, or an inflammatory reaction along the periwound or the extremity itself.

Note: while infection of venous wounds does occur it is often mistaken as the lone cause of redness along the extremity or peri-area of the wound. More commonly, this redness (erythemia) is related to an inflammatory process common with venous wounds (see a great explanation below*). If this problem is preventing the application of Wound Vac therapy then I recommend a Medrol dose pack which typically does this trick in reducing the inflammatory process.

2. Fragile or weeping skin tissue proceeding from the borders of the wound out to the greater part of the lower extremity (disallowing adhesion of wound vac drape or duoderm thin without the further opening of wounds along the extremity).

This being said, you can treat fragile or weeping skin just a few inches away from the wound with a few simple tricks.

First, on outright weeping skin a recommend a layering process that starts with the application of Non-sting skin prep followed by anti-fungal powder.  Alternatively repeating (at least 10 repeated applications) the application of these two products achieves two goals as the weeping areas are covered in a way that limits their drainage and the skin prep provides a great tacky surface for which the wound drape to adhere.

Second, along the edges beyond the weeping or fragile skin tissue place a Duoderm thin (ConvaTec). I have found that Duoderm Thin is about the only dressing that prevents the fluid from working its way under it a high draining wound with or without NPWT.  I also recommend placing stoma paste (ConvaTec) in the trenches of skin that the Duoderm Thin can’t secure to (See the following image). Once hardened place the Duoderm Thin over the Stoma Paste.

Skin Tissue after Compression for Venous Etiology WoundsFinally, at this point place the VAC Foam in the wound bed. I recommend the  the V.A.C.® GranuFoam™ Bridge Dressing (See Picture Below). This dressing allows you to concisely weave the pre-sized bridge dressing through the multilayer compression dressing. When applying the wound drape place skin prep to skin (that is intact) and over the Duoderm Thin to provide a more wound drape dressing.

“Venous reflux (or valve failure) or other vein conditions can lead to increased pooling of blood, causing venous hypertension (increased pressures in the veins of the lower leg), which leads to the pooling of blood. These venous conditions may come from more superficial veins (like varicose veins), deeper veins (related to deep vein thrombosis or DVT) or from perforator veins, which connect the veins of the superficial and deep vein systems. When these high pressure conditions exist, fluid can leak out into the surrounding tissues, inflammation of the tissues occurs, and the normal transfer of nutrients and oxygen to the tissues is impaired. Over time, the diminished level of nutrients and oxygen and the inflammation created causes damage to the surrounding tissues, which can result in skin discoloration and tissue death” (retrieved from http://www.veintreatment.com).

Multilayer Compression Tips (What to do under the wraps)

Here are pathways for treating and protecting skin and wounds under multilayer compression bandaging (Profore or dynaflex) for patients with venous hypertension: Please add to this list as you wish. This was last revised  06/25/2010.

Dry Skin

Dry flakey skin – Moisturizer or thicker moisturizer.

Dry denuded skin – Xeroform.

Dry lightly reddened skin – A moderate strength steroid  (Topicort), change underlying padding to pure cotton cast padding.

Dry itching burning skin – Viscopaste wrap as first layer.

Moist Skin

Moist denuded skin – wound veil (Smith and nephew) covered with alginate. I recommend the wound veil cover because it will prevent the alginate from binding with the denuded tissue.

Draining wound – alginate or a beveled foam dressing. Note that foams have a tendency to dig into the skin around the edges, so it is important cut and taper around the foam edges.

What antimicrobials can I place on the wound that will last seven days?

Moderate or High draining wounds – Consider Iodosorb or Acticoat 7  flex. Remember to put lots of protective cream (EPC) around the peri-wound. Consider changing the  compression wrap twice a week.

The dressing has a foul smell after a few days

Consider a carbon dressing over the primary antimicrobial, debride, treat infection if present, change the dressing more often.

Still Edematous

Swollen moist red skin with new breakdown (even with 30-40mmHg compression) – Typical with fluid over load patients including renal disease. Treat the  etiology.

Swollen extremity with reddened skin and new onset calf pain – Rule out DVT.

Edematous knee to thigh after compression – Rule out Lymphedema and consider Edema Wear or Tubigrip from the bottom of the knee (just below the top of the initial compression device) to the top of the thigh. Consider placing a strip of foam dressing just under and over the top of the multilayer compression device if the top of the compression dressing is cutting into the skin (because of the edema).

Swollen Forefoot after Compression – Typically this is a result of the compression dressing being pushed up by mechanical means (related to poor fitting shoes or human intervention). Recommend the patient wear shoes with larger toe space such as Crocs or a surgical shoe. Consider placing an extra turn of the wrap or a 4×4 of plain foam over the  swollen area. Also place a thick barrier cream such as EPC cream over the forefoot to provide some tact in the area.

Swollen Toes after Compression – Consider gently wrapping the toes by first separating each toe with a foam dressing to prevent toe to toe pressure. Then place extra padding over the toes before you finish wrapping the toes with Coban. The elastic layer shouldn’t be placed over the toes along with the Coban,  as this my apply to much pressure.

Infection

Swollen red skin with open wound and new onset fever or pus – Rule out infection, culture wound, antibiotics.

Inflammation

Bright reddened skin   (Inflammatory with no signs of infection) – Topicort topical, medrol dose pack, Could also be related to allergy such as sulfa, bacitracin, or latex. Note that redness from a topical sulfa allergy can clear up in a matter of minutes once removed.

Recurrent reddened skin with an open non-healing wound  – Consider differential diagnosis including autoimmune or another micro-occlusive disorder. Micro-occlusive disorders are covered in the Scottsdale Wound Management Guide (which can be purchased at swmghandbook.com). – Topicort to the wound bed and Prednisone oral weening over 6 weeks.

Dermatology

Reddened vessels around hair follicles – Rule out  folliculitus

Smaller reddened vessels (in groups or singular) – Consider treatment as fungal infection. Anti-fungal ointment for small area fungal breakouts.

Itchy rash over the majority of lower extremity below and maybe just above the knee to the thigh  (If using latex compression  wraps) , also possible systemic effects including puffy face, etc… – Rule out latex allergy, Consider Medrol dose pack, Benadryl, and Profore LF (Latex Free)

Shriveled skin – This is a common situation which happens during the first few weeks of compression therapy. The skin typically tightens on its own.

Adherent dry or dead tissue build up – Lotions (without alcohol)  and /or mist therapy to loosen. Once loose use a pick-up to remove.

Pain

Vague recurrent pain with application of compression dressing – To much tension, consider less compression to the extremity. Including placing Tubigrip instead of Coban on the final layer. Insure that ABI indicates no arterial component.

Recurrent pain over bone with the application of compression dressing – Assess the skin for areas of bruising or open skin. Cover the area with a hydrocolloid.

Recurrent pain over small protruding bone with the application of compression dressing – Cut out foam around the prominence with the idea of offloading the small protruding bones from the pressure of the wrap.

Recurrent pain over prominent shin bone with the application of compression dressing – Build up an offloading  layer of cast padding to the shins sides, then place extra cast padding over the shin down to the anterior ankle .

Pain related to wrap cutting in to skin of fluted lower extremity.  Note that fluted refers to a thick upper calf and a narrow distal third of the lower extremity – Assess for rolled undulating skin with straight indentations or openings into the skin that match up with the wrap. Place extra cotton layers around the lower third of the dressing to build the area up. This protects the skin and helps prevent the wrap from sliding down.

Swollen extremity with reddened skin and new onset calf pain – Rule out DVT

Pain with removal of dressing – Consider using Xeroform,  Adaptic, Mepetel or Comfort 2 Wound Veil.  Saturate the dressing with saline to facilitate removal of dry drainage from viable tissue.

No Improvement in Wound Size:

Consider a vascular consultation starting with a Venous Doppler R/O incompetent perforators.

Consider if wound stalling is related to chronicity or infection. Treat with collagen and /or with seven day anti-microbal dressing.

Consider secondary etiologies such as lymphedema, hypercoagulable states, autoimmune disorders, malignancy, etc…

Unable to convert patient to stockings (without increased swelling and or reopening of wounds)

Consider a vascular consultation starting with a Venous Doppler R/O incompetent perforators.

Try different compression stocking companies including more expensive brands that may have true and appropriate compression(yes there is a difference in quality between brands).

Poor health precludes vascular intervention – Palliative care (keep the patient in multilayer compression).

Revised 12/02/2010 ml

Venous Wound Compression Therapy Options

Elasticized tubular gauze (e.g. Tubigrip)
Pressure: Single layer ( low 8, medium 11, high 13mmHg), with double layer ( low 16, medium 22, high 26mmHg).
Indications:
Mild to moderate venous insufficiency
A way to modulate pressures by replacing Coban in Multi-layer compression wraps

Single layer elastic wrap – long-stretch (ACE Wrap, Sure Press (ConvaTec))
Pressure: 20 mmHg
Indications:
Initial treatment of moderate venous insufficiency
Reusable
Note: If the patient is placing the wrap they need to be able to accurately wrap the dressing without gaps.

Single layer elastic wrap – short-stretch  (Comprilan (BSN Jobst)
Pressure:  19-29 mmHg
Indications:
Initial treatment of moderate venous insufficiency
Reusable
Note: If the patient is placing the wrap they need to be able to accurately wrap the dressing without gaps.

Compression stockings (Jobst, Mediven, Juzo, Sig-Varis. Allegro, Medi-strumpf, Therapress Duo)
Pressure: 30-40 mmHg
Indications:
Severe edema related to venous insufficiency or lymphedema
Maintenance therapy when initial edema, wound , and drainage has resolved

Pressure: 20-30 mmHg
Indications :
Moderate edema related to venous insufficiency or lymphedema
Treatment for chronic venous insufficiency
Note: Consider custom stockings for patients with: 1. a large calf with narrow ankle  2. lipodermatosclerosis

Multi-layer compression Wraps (Dynaflex (Systagenix), Profore (S&N), and Dynapress (Systagenix)
Pressure: 30-40 mmHg
Indications:
Severe edema related to venous insufficiency or lymphedema
Initial treatment choice for edema and exudate.
Appropriate for ambulating and non-ambulating patients
Changes 1 to 2 times a week depending on underlying wound and peri-wound conditions*
Best applied by a wound specialist

Inelastic (Unna’s boot or Duke’s boot) ViscoPaste (S&N), Gelocast (BSN)
Pressure: with one wrap of coban (adherent compression wrap) 30mmHg,  with two wraps of coban 40mmHg
Indications:
Severe edema related to venous insufficiency
Appropriate for ambulating and not as effective for non-ambulating patients.
Changes 1 to 2 times a week depending on underlying conditions*
Best applied by a wound specialist

Orthosis Circ-Aid (Coloplast), inelastic  (Farrow-wrap)
Circ-Aid T-3M Pressure:  20-30, 30-40, 40-50 mmHg
Indications:
Moderate to severe edema related to venous insufficiency or lymphedema
Treatment for chronic venous insufficiency (20-30mmHg).
Appropriate when initial edema and drainage are reduced.
For Patients who have difficulty placing elastic stockings.  Both Circ-Aid and Farrow wraps have velcro closure mechanism.

Farrow-wrap Pressure: 15-30mmHg
Indications:
Mild to Moderate edema related to venous insufficiency or lymphedema
Treatment for chronic venous insufficiency

Appropriate when initial edema and drainage are reduced

For individuals who have difficulty physically placing their stockings.These  products have Velcro closure mechanisms that allows for staged placement. Making the overall effort more reasonable, however, there is a learning curve that must be considered when suggesting these products to your patients.

Venous Wound Basics

There are several more common types of wounds, other than surgical or pressure related wounds, that are common in the clinical setting. These include (but are not limited to) arterial, venous, and diabetic ulcers. The following will briefly discuss ideas related to the specific cause, diagnostics, appearance, and treatment of a venous wound etiology.

Venous ulcers form by a complex cascade of physiological events in the venous circulation related to venous hypertension. Diagnostics used to confirm venous hypertension include pneumoplethysmography (maximum venous outflow), venous photoplethysmography, and bi-directional color doppler.  Treatment for venous ulcers includes compression wrap bandages, intermittent pneumatic compression, and apligraf.   High compression bandaging is considered the gold standard of treatment of venous leg wounds, yet the majority of published clinical data indicate that only 65% of ulcers are likely to be healed within 24 weeks of appropriate compression therapy, with 20% of ulcers remaining unhealed after more than 50 weeks (1).

(1) Skene AI, Smith JM, Dore CJ, Charlett A, Lewis JD. Venous leg ulcers: a prognostic index to predict time to healing. BMJ 1992; 305(6862): 1119-21.

Common Terms include:

FIBRINOUS– Accumulation of fluids and fibrin (a stringy insoluble protein).

HEMOSIDERIN STAINING – Hemoglobin deposited in tissues. Appears as brownish patches. Symptomatic of venous disease.

LIPODERMATOSCLEROSIS – an induration and erythematous hyperpigmentationof the leg.

MALLEOLUS – A common location of venous wounds located at either of the two rounded protuberances on the side of the ankle, the inner formed by a projection of the tibia and outer projection of the fibula.

PERIPHERAL VASCULAR DISEASE (PVD) – Alterations in the arteries and veins of the extremities; those conditions which interfere with adequate flow of blood to or from the extremities. Peripheral vascular disease broadly describes the underlying pathology of venous stasis ulcers and arterial ulcers.

VARICOSITIES – swollen, twisted veins.

VAVULAR INCOMPETENCE – Refers to damaged valves in the perforator veins of the legs; results in poor venous return to the heart. Valvular incompetence is the underlying pathology of venous stasis ulcers.

VENOUS HYPERTENSION
Patients with varicose veins or nonfunctional venous valves after deep vein thrombosis develop ambulatory venous hypertension, that is, distal venous pressure remains elevated despite ambulation. This constant venous hypertension seems to cause white cell and fibrin buildup, which impairs capillary blood flow or traps growth factors. Macromolecules pass into the dermis and eventually cause the hemosiderin deposition and brawny induration in the distal leg (gaiter area) characteristic of chronic venous insufficiency.

VENOUS INSUFFICIENCY – Stagnation of the normal flow of blood from the lower extremities to the heart due to valvular incompetence; also called venous hypertension.

VENOUS STASIS – Stagnation of the normal flow of blood from the lower extremities to the heart due to valvular incompetence; also called venous hypertension.

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